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ANTIHYPERLIPIDEMIA AGENTS Plasma lipids Transported in bloodstream in form of macromolecular complexes of lipid and known as lipoproteins Two major clinical importance/sequelae of high lipid Acute pancreatitis atherosclerosis Hyperlipoproteinemia Hyperlipidemia Lipoprotein disorders Primary hypertriglyceridemias Primary chylomicronemia Familial hypertriglyceridemia Familial combined hyperlipoproteinemia Familial dysbetalipoproteinemia Primary hypercholesterolemias Famimial hypercholesterolemia Familial ligan-defective apolipoprotein B Familial combine hyperlipoproteinemia Lp(a) hyperlipoproteinemia Secondary hyperlipoproteinemia Lipid-lowering drugs Several drugs are used To decrease plasma LDL-cholesterol Drug therapy is only one approach Dietary measures are the first [...] | 19th January, 2010 | More News
Metabolism and excretion
Pharmacokinetic knowledge
Will determine of drugs of its
Route of administration
Dose
Latency of onset
Time of peak action
Duration of action
Frequency of administration
Pharmacokinetic processes
Transport of the drug across the biological membrane
Biological membrane
is a layer that acts as a barrier within or around a cell.
Thickness – 100 A0
It is a lipid bilayer.
Composed of a double layer of lipid-class molecules,
phospholipid and
cholesterol
with occasional [...]
Absorption and Distribution
Pharmacokinetics - WTBDTTD
Quantitative study of drug movement:
In
Through of the body
Out
•It is dealing with the dose-concentration part
•three primary processes of pharmacokinetics are
–absorption,
–distribution, and
–elimination
•It determine
–how rapidly and
–for how long the drug will appear at the target organ.
»Katzung (9th edition)
Principles of Pharmacokinetic
a drug should be able to reach its intended [...]
Introduction to Pharmacology
Why should we learn Pharmacology?
A) It is a basic science.
B) It is an applied science.
C) No idea.
Answer:
Definitions of Pharmacology
Science and knowledge of drugs
Relevant to effective and safe use for medicinal purpose.
Dealings with interaction of exogenously administered chemical molecules (drugs) with living systems.
Katzung definitions: study of substances that interact with living systems through chemical processes,
binding to [...]
Resveratrol …an Investment against Influenza A Virus protection?
Introduction
Influenza A Virus
Influenza viruses are enveloped viruses with segmented, single‐stranded, negative‐sense RNA genomes. Every year, influenza epidemics cause numerous deaths and millions of hospitalizations, but the most frightening effects are seen when new strains of the virus emerge, causing worldwide outbreaks of infection. Recent reports of direct avian‐to‐human transmission of influenza make the prospect of [...]
Isolation of neutrophils
Materials
Citrate (0.32%) as anticoagulant
4.5% dextran T-500 in PBS (sterile), room-temperature
Ficoll-Conray solution (density, 1.077 g/ml), sterile
PBS
20 x concentrated PBS, ice-cold
Turk’s solution
15-ml conical plastic centrifuge tubes
Refrigerated low-speed centrifuge
Lucigenin stock: 10 mM – final concentration of 0.1 mM.
Buffer Saline Albumin
Stimulant stock: 1mg PMA /ml
CL Monitor: Berthold Multi-Biolumat LB 9505 C Luminometer
Measuring vials
Neutrophil source: were blood obtained [...]